Communicators

Medigene AG: Additional European patent granted for Medigene's DC vaccine platform

Business news for the stock market

Martinsried/Munich (08.01.2019) - Medigene AG (FSE: MDG1, Prime Standard, SDAX) reported today that an additional European Patent was granted for its dendritic cell (DC) vaccine platform.

The European Patent EP2918673 covers an isolated mature dendritic cell or an isolated population of mature dendritic cells obtainable by a method for in vitro maturation as e.g. disclosed in the patent and has a life-span until 2027. Medigene holds an exclusive license to the patent that was issued to Helmholtz Zentrum München.

Prof. Dolores Schendel, CEO and CSO of Medigene AG, comments: "We are pleased that this new patent adds additional intellectual property protection to Medigene's DC patent portfolio that already covers our proprietary methods to isolate and mature dendritic cells as well as our DC maturation cocktail."

Medigene is currently conducting a Phase I/II clinical trial with its DC vaccines in acute myeloid leukemia and has recently published topline interim data of this study (press release from December 19, 2018: https://bit.ly/2CpWolq).

About Medigene's DC vaccines: In addition to Medigene's development focus on T cell-receptor modified T cells (TCR-Ts), the Company has developed a new generation of antigen-tailored dendritic cell (DC) vaccines.

Dendritic cells (DC) can take up antigens, process them and present peptides on their surface in a form that can induce antigen-specific T cells to mature and proliferate. In this way, T cells rec-ognize and eliminate tumor cells which bear the same antigen peptide on their surface. Dendritic cells can also induce natural killer cells (NK cells) to attack tumor cells. The scientific team of Medigene has developed new, fast and efficient methods for generating autologous (patient-specific) mature dendritic cells which have the relevant characteristics to generate very strong T cell and NK cell immune responses. The dendritic cells can be loaded with various tumor anti-gens to treat different forms of cancer. Since an immune response builds up over the total time of administration of the DC vaccine, this form of therapy is particularly designed for patients who suffer from a tumor disease which has been reduced to such an extent by chemotherapy that the prevention of the recurrence of the tumor disease is the main goal.

Medigene AG (FSE: MDG1, ISIN DE000A1X3W00, Prime Standard, SDAX) is a publicly listed biotechnology company headquartered in Martinsried near Munich, Germany. The company is developing highly innovative immunotherapies to target various forms and stages of cancer. Medigene concentrates on the development of personalized T cell-based therapies with the fo-cus on T cell-receptor modified T cells (TCR-Ts) and has associated projects currently in pre-clinical and clinical development. For more information, please visit http://medigene.com

This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene® is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only.

Contact Medigene AG

Julia Hofmann, Dr. Robert Mayer

Tel.: +49 - 89 - 20 00 33 - 33 01,

email: investor@medigene.com

emitter: Medigene AG

address: Lochhamer Straße 11, 82152 Planegg

country: Germany

contact person: Medigene PR/IR

phone: +49 89 2000 33 3301

e-mail: investor@medigene.com

website: www.medigene.de

ISIN(s): DE000A1X3W00 (share)

stock exchanges: regulated market in Frankfurt; free market in Stuttgart, free market in Munich, free market in Hamburg, free market in Dusseldorf, free market in Hannover; open market in Berlin, Tradegate